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The workshop on Disruptive Information and Communication Technologies for Innovation and Digital transformation, organized under the scope of the DISRUPTIVE project (disruptive.usal.es) and held on September 12, 2022 in Valladolid, aims to discuss problems, challenges and benefits of using disruptive digital technologies, namely Internet of Things, Big data, cloud computing, multi-agent systems, machine learning, virtual and augmented reality, and collaborative robotics, to support the on-going digital transformation in society. The main topics included: Intelligent Manufacturing Systems; Industry 4.0 and digital transformation; Internet of Things; Cyber-security; Collaborative and intelligent robotics; Multi-Agent Systems; Industrial Cyber-Physical Systems; Virtualization and digital twins; Predictive maintenance; Virtual and augmented reality, Big Data and advanced data analytics; Edge and cloud Computing; Digital Transformation. The workshop program included 6 accepted technical papers, 2 invited talk and a networking session. This volume contains 6 of the papers presented at the Workshop on Disruptive Information and Communication Technologies for Innovation and Digital Transformation. This workshop was organized by ICE (Institute for Business Competitiveness of Castilla y León), UVa (University of Valladolid) and mainly supported by the European Regional Development Fund (ERDF) through the Interreg Spain-Portugal V-A Program (POCTEP) under grant 0677_DISRUPTIVE_2_E (Intensifying the activity of Digital Innovation Hubs within the PocTep region to boost the development of disruptive and last generation ICTs through cross-border cooperation).